However, in the BCS mice the OBF1 transgene is expressed already before EBF1 and this altered sequence of expression compromises the development of the proB cells.
A disruption of the normal sequence of expression of genes that make these organs is responsible for this (Thewissen et al. 2006).
This ordered sequence of expression as a function of Notch activity levels fixes an ordered sequence for the threshold values of the regulatory functions in our modeling approach.
In any case, the history of PfEMP1 expression is recorded in the antibody repertoires that accumulate in individual hosts, regardless of the molecular basis of the sequence of expression [4], [17] [19].
The sequence of expression of the fusion-proteins corresponded to their respective gene expression kinetic class, with IE2-EYFP being detected from 6 hpi, ppUL83-EYFP from 24 hpi and ppUL32-EYFP in the late phase at 72 hpi.
Studies on stage- and gender-specific expression profiles with parasites of various developmental stages have been carried out with different methodological approaches, from manual sequencing of expression sequence tag (EST) to full-length cDNA cloning, microarray hybridization, and random sequencing [15], [16], [17], [18], [19], [20], [21].
The morphs also differed in the sequence of expression of male and female functions (Fig. 1; the order of flowering is numbered).
The developmental sequence of expression of these genes provides clues that help further narrow the choices of functional role for ABP.
High-throughput sequencing of expression data provides compelling evidence that the long held hypothesis "one gene produces one protein" is far less common than previously thought.
This sequence of expression is followed by the basic helix-loop-helix, pro-neural gene NeuroD and the Tbr2-related layer VI marker, Tbr1 (Hevner et al., 2006).
