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However, in addition to being faster and significantly less expensive, this sequencing technology avoids the arbitrary loss of genomic sequences inherent in random shotgun sequencing by bacterial cloning because it amplifies DNA in a cell-free system.
In summary, we highlighted the importance of modifying vector design for co-delivery of highly similar sequences inherent to genome-editing nucleases, and demonstrated significant improvement in the use of IDLVs for delivery of ZFNs and donor templates for genome modification.
Genetic sequences inherent to a genome exhibit specific common statistical features, whereas genes recently horizontally transferred into the genome show the specific statistical features of their original genome.
As a result, with the proteinaceous gas vesicle system the potential effects associated with co-introduction of DNA sequences, inherent in viral or phage based vaccines, can be completely avoided.
Effective SNP discovery in complex genomes would require additional analysis to consider duplicate loci and to identify and eliminate pseudo-SNPs produced by misassembly of paralogous and homoeologous sequences inherent to polyploid genomes.
We hypothesize that the specific satellite sequences inherent to the Cathartidae may represent unique genomic signatures that could help resolve the long disputed taxonomic position of this avian family (e.g., [ 55, 57, 58]).
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It lacks, however, the capability to address the time-sequence inherent in provider interactions.
These methods of analysis did not include reference to the longitudinal time sequence inherent in these data.
Since the structural integrity is sequence-inherent and does not depend upon the presence of the remaining protein, this β-hairpin represents an independent structural motif and so provides a useful model of this type of protein architecture and its relation to biological function.
In order to further test the sensitivity of our method and to detect possible differences in the sequencing yield, inherent to each sequencing run, we conducted a complementary experiment.
Because of the reference sequence bias inherent to the sequencing technology, these analyses were repeated for sites with more stringent quality cutoff of Q40.
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CEO of Professional Science Editing for Scientists @ prosciediting.com