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We explore the potential role for microRNAs as therapeutic tools to modulate target RNA sequences implicated in disease states.
Working together, scientists from UCLA's Broad Center for Regenerative Medicine and Stem Cell Research and its Center for Duchenne Muscular Dystrophy focused on the largest known human gene, where the DNA sequences implicated in DMD are nestled in among many others.
When one of the parental sequences implicated in an event could not be inferred within the sequence alignment, it was denoted as "unknown parental".
For example, GO annotation revealed 320 sequences implicated in general stress responses, including heat shock factor binding proteins (Table 4).
Thus, combinatorial Insm1/Neurod1/Foxa2 binding sites are enriched for sequences implicated in β-cell dysfunction in humans.
Therefore, it is important to learn the fine structure of DNA damage, in particular, proto-oncogenes, tumor-suppressor genes, and other DNA sequences implicated in tumorigenesis.
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This may be due to differential binding of Prn variants to host receptors, as the variable region is located close to the RGD sequence implicated in attachment [17], [47] (Fig. 1A).
The bla CTX-M-15 gene located on these plasmids was found downstream of the ISEcp1 insertion sequence implicated in its expression [ 9].
The overall identity percentage between P. margaritifera protein sequences potentially implicated in the biomineralization process and protein sequences from gastropods ranged from 27% (Veliger mantle 1 from H. asinina) to 100% (Calmodulin from Conus cuneolus).
The overall identity percentage between P. margaritifera protein sequences potentially implicated in the biomineralization process and protein sequences from the other bivalves ranges from 28% (EP protein precursor from Mytilus edulis) to 58% (bone morphogenic protein type 2 receptor from Crassostrea gigas).
The overall identity percentage between P. margaritifera protein sequences potentially implicated in the biomineralization process and protein sequences from the Pinctada genus is ranging from 24% (C-type lectin 2 from P. fucata) to 95% (Ferritin-like protein from P. fucata).
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