Sentence examples for sequences given the from inspiring English sources
In the past 5 years, there have been many breakthroughs in the development of computational methods that allow the selection of novel sequences given the structure of a protein backbone.
For the TM sequences, given the high number of possible hydrophobic residues in the helical region, there are a larger number of possible hydrophobic contacts with the ribosomal proteins L4 and L17 at the constriction point of the tunnel, as well as a smaller number of possible contacts with L39 near the exit pore.
The "discriminatory" aspect of the key new (sequence-dependent) contribution is most evident in forms like that above, where we have a likelihood ratio for the observed sequences given the different label "classifications" chosen.
These expected values are determined by the conditional probability distribution over tag sequences, given the training corpus and the current HMM parameters, and can be obtained using the forward and backward probabilities as described above (and thus, conditioned on the entire corpus).
The model fits the parameters of this bivariate general discrete distribution of rates across the sequences given the phylogeny.
It then chooses the pairs of preclusters to be NW aligned by performing all-against-all megablast [23] comparison of these preclustered sequences using a custom nucleotide similarity matrix, and filtering the megablast matches by comparing the score achieved to that expected for two sequences given the largest similarity cutoff requested.
As anticipated from the similarity network (Figure 2), the classification of B Type sequences gave the poorer results.
In addition, 0.35% of the sequences gave the best hit to the human genome, with almost 100% of identity, indicative of exogenous contamination.
Skyline plot analyses of larger datasets (up to 200 HVRI+II sequences) gave the same results as the 81 sequence datasets (data not shown).
The sequences giving the highest scores were retried to construct the phylogenetics dendograms.
Yet many sequences give the same structure, and many structures provide the same function [ 120, 126- 128].
