Sentence examples for sequences critical for from inspiring English sources

Transgene rescue experiments showed that a dCTCF protein lacking sequences critical for CP190 interactions was almost as effective as wild type in rescuing the phenotypic effects of a dCTCF null allele.

Abi-2 is a novel protein that contains an SH3 domain and proline-rich sequences critical for binding to c-Abl.

Surprisingly, further biochemical and quantitative microscopy studies revealed that restraining the two-fold interface hinders externalization of buried VP N-termini, which contain a phospholipase A2 domain and nuclear localization sequences critical for infection.

In fact, many nucleolar proteins have been shown to contain RNA-binding sites coincident with sequences critical for nucleolar localization.

The internal ribosome entry site (IRES) located in the 5′-UTR directs cap-independent translation, whereas the 3′-UTR contains sequences critical for viral replication and translation.

Intragenomic site-specific mutation rates can vary across orders of magnitude and it has subsequently been suggested that mutation rates may be higher in sequences critical for adaptation, leading to rapid divergence even among closely related species (King & Kashi, 2009).

We found a high degree of sequence conservation at this site in species from human to chicken with complete identity of the "seed" sequence, critical for microRNA binding.

We examined the changes in the amino acid sequence critical for IgG1b12 binding in sequential viruses obtained from patients ITM60, NYU104 and 3506.

Bauer et al. applied TALENs to modulate the activity of an enhancer sequence critical for erythroid expression of BCL11A, a gene implicated in hemoglobin disorders 66, 67.

Transcription of the U6 product initiates with a guanosine nucleotide, placing some constraint on the selection of target sequences in the genome, which optimally consist of the motif G-N19-NGG, with the final three nucleotides (the PAM sequence) critical for cleavage.

The TARE regions and a subtelomeric class of var genes - known as the upsB-type var genes - are also enriched in the cis-acting element SPE2, a bipartite 12 base pair sequence critical for regulation of var gene silencing that has recently been shown to be bound by a member of the ApiAP2 transcription factor family, P. falciparum SPE2 interacting protein (PfSIP2) [ 9].