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Targeting expression to the mammary gland; intronic sequences can enhance the efficiency of gene expression in transgenic mice.
It is also known that many mono-phosphorylated sequences can enhance the rate of subsequent second/multi-phosphorylation of the same protein.
Based on (a) experimental data clearly showing a large degree of miRNA binding in coding regions (b) our finding that seed sites in coding sequences are under negative selection (c) our finding that miRNA target sites in coding sequences can enhance regulation mediated by sites in 3' UTRs, it seems clear that miRNA target sites in coding sequences are functionally important.
Specific MRI sequences can enhance the diagnostic and prognostic evaluation of patients with acute brain injury.
A growing number of plant expression studies on chimeric RNA have demonstrated that such intron sequences can enhance the level of protein expression, a phenomenon termed Intron-Mediated Enhancement (IME) [ 4- 10].
As it is known that specific DNA sequences can enhance or mediate recombination, we have in this study targeted the vast database of known human HLA-DRB1 alleles in the quest for possible sequence motifs that would enable recombination.
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These data provide the first indication that in vivo use of a translocation sequence can enhance delivery of therapeutic peptides and increase anti-tumor immunity through a simple and safe mechanism involving enhanced penetration of the skin barrier.
Microbial genome sequencing can enhance diagnosis and control of infectious diseases (1, 2 ).
We demonstrate benchtop sequencing can enhance hospital infection control through high precision support and rejection of transmission using genetic data.
This study provides strong evidence in two major healthcare-associated pathogens, S aureus and C difficile, that benchtop sequencing can enhance hospital infection control through high precision support and rejection of transmission using genetic data.
The activity of the SCBV-IM enhancer was demonstrated in transient assays first by identifying sequences that are necessary for high levels of transcription and then by identifying sequences that can enhance transcription from a heterologous promoter.
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