In this map/image, the brighter regions depict the areas where the first two frames of the caltrain sequence are structurally dissimilar.
Though ρ is a function of sequence and not structure, the dispersion ratio, like the methods from which it was inspired (e.g. ET, ESF, SWAKK), leverages the fact that adjacent residues in the sequence are structurally proximal.
The bSSFP sequence is structurally very similar to the spoiled gradient echo sequence; however, as it does not spoil but instead re-focuses the transverse magnetisation at the end of each TR interval, it makes more efficient use of the available magnetisation.
Candidate SV regions are refined through further local alignment, and finally SNPs and small indels are determined using an alignment-based assembly once the genomic sequence is structurally similar and reads that span SV breakpoints are properly aligned.
There is a single TIS located in exon 2. Otherwise, the ancestral AMBN sequence is structurally similar to that of most mammalian AMBN and, in particular, possesses all the important positions and domains reported above.
We also note that as in [ 14], we excluded from this analysis the enigmatic INE-1 element [ 53] that can be found in many transcripts [ 54], since this repetitive sequence is structurally distinct from all other TEs in the Drosophila genome.
Using three strict criteria, we found that a considerable number of TFs bind DNA sequences that are structurally conserved, independent of sequence conservation in S. cerevisiae.
The majority of these TFs bind GC- and C-rich sequences that are structurally related to each other, suggesting the possibility that a significant portion of the sequence elements listed above might indeed be recognized by one or a limited number of TFs.
Segments of protein sequence that are structurally inaccessible or part of an active site are generally intolerant of such small insertions whereas segments located on the outer surface of the protein or in connector regions are more readily accepted [26], [27].
Despite considerable variability in size and sequence, Hsfs are structurally and functionally conserved throughout the eukaryotic kingdom.
