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The above results suggest that the two ChoK isoforms investigated, besides their similarity in their primary sequences, are implicated in different metabolic pathways.
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Many variants of this gene sequence are implicated in melanoma risk (reviewed in [ 14, 15]).
A dyad OCT-binding sequence was implicated in the maintenance of the unmethylated state of the mouse H19 ICR in a cell culture model (26).
An additional cluster contained viral transaldolase (talC) sequences, which are implicated in cyanophage-mediated carbon metabolism during the dark cycle of host cells [27], [45].
Combining editome sequencing from ADAR1 knockdown cells and protein immunoprecipitation, Wang et al. strengthened this hypothesis by identifying an enrichment of HuR-binding sequences, which are implicated in transcript turnover and processing, around editing sites and on ADAR-bound transcripts, respectively [ 43].
Interestingly, the drive to collapse, which implies a drive to minimize the interface between the IDR and the surrounding solvent, can also give rise to the significant aggregation and solubility problems as is the case with several glutamine, asparagine, and glycine-rich sequences that are implicated in amyloid formation and phase separation.
Remarkably, sequences from WD6 that are implicated in PKC binding include both β-strands A (234-DIINALCF-241) and C (255-SIKIWD-260) of blade 6 [ 42- 44, 94- 96].
This review article brings together comprehensive information regarding nuclear foci formed by transcripts of different mutant genes that contain simple sequence repeat expansions and are implicated in the pathogenesis of human hereditary neurological diseases (Fig. 1).
Among the important target sequences of this miRNA that are implicated in MB, one of the most interesting gene is the mRNA of histone deacetylase 2 HDAC2.
A significant proportion of sequences in our mantle EST collection are implicated in binding, and particularly in ion binding.
Recurrent interactions between the input and output of a songbird cortico-basal ganglia pathway are implicated in vocal sequence variability.
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Justyna Jupowicz-Kozak
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