Exact(24)
By contrast, because gene-regulatory sequences are frequently associated with temporally and spatially specific gene-expression patterns, changes in these regions may modify the function of only certain cell types at specific times, making it more likely that they will confer an evolutionary advantage12.
However, in eukaryotic genes the coding sequences are frequently "split" in the genome a discovery reached independently in the 1970s by Richard J. Roberts (the author of this article) and Phillip A. Sharp, whose work won them a Nobel Prize in 1993.
The structures formed by these classical repeat families can be divided into closed structures with a fixed number of repeats in a clearly discernible domain (e.g. the β-propeller composed of WD40-type repeats), and open structures where the number of repeats can be highly variable from protein to protein and where insertions of non-repeat sequences are frequently observed.
In this sense, REP sequences are frequently located in regions between convergent genes.
In eukaryotes, centromeric sequences are frequently organised as highly repetitive tandem arrays that stretch over extensive regions of chromosomal DNA.
By now, it is well known that TE-derived sequences are frequently incorporated into the exons of host mRNAs [ 12].
Similar(36)
However, the practical implementation of such pulse sequences is frequently complicated by unexpected instrument behavior.
Significantly, we found that 34.69% (493/1,421) of the sequences were frequently hypermethylated in hESCs (array signal>0.7 in≥25% (2/8) of the samples).
Moreover, specific 16S rRNA gene sequences were frequently most similar to those recovered from other insect guts (i.e., they were not simply soil-dwelling species incidentally found in the beetle guts).
Furthermore, the reading frame context of coding sequences is frequently ignored, or the individual frames are not taken into account.
Although identical sequences were frequently picked up in independent experiments, altogether more than 160 unique sequences encoding peptides with potential gliadin binding activities were identified (data not shown).
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