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Active compounds appear to selectively target extended AT sequences and induce changes in kinetoplast DNA minicircles that cause a synergistic destruction of the catenated kinetoplast DNA network and cell death.
Homing endonucleases (HEs) are enzymes that specifically target long (14 40 bp) DNA sequences and induce double-stranded breaks (dsb) [3].
It was shown to associate with the telomeric rep20 sequences and induce deacetylation of histone H4 complexes thus spreading gene repression ∼50 kb into chromosome internal regions, regions that include many var genes.
Previous studies show that (nuclear factor kappa B) NFκB, (interferon regulatory factor) IRF-1 and P53 proteins directly bind to IFN gene sequences and induce transcription.
miRNAs bind to complementary sites on target mRNA sequences and induce cleavage of the transcript or repress translation (Ambros, 2004; Bartel, 2004).
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In the case of the C1701 data, it seems that the phylogenetic tree is more a confounder of the data in the traditional sense, wherein the tree is associated with both the HLA data and the sequences and induces false correlations between HLA allele and sequence.
Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and induced T-cell responses.
Moreover, we proposed flagellin as a carrier molecule to display the cell-adhesive RGD (Arg-Gly-Asp) peptide sequence and induce cell adhesion on the coated surface.
A broad general distinction between plants and animals lies in the targeting of endogenously produced miRNAs; in plants, miRNAs are usually perfectly or nearly perfectly complementary to their target genes and induce direct mRNA cleavage by RISC, while animals' miRNAs tend to be more divergent in sequence and induce translational repression.
A wide variety of genetic mechanisms ensure that these events occur in proper sequence and induce cell death when a process is incorrect.
In the active form, DevS and DosT autophosphorylate and induce phosphorylation of DevR, which in turn, can bind its DNA recognition sequence and induce expression of the DevR regulon resulting in the activation of the dormancy program [ 76].
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