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Global DNA hypomethylation generally occurs in centromeric repeats and repetitive sequences and contributes to carcinogenesis by causing chromosomal instability, reactivation of transposable elements, and loss of imprinting [ 25].
Histone H3 interacts with essentially all different classes of genomic DNA sequences and contributes to the regulation of multiple aspects of chromatin structure and function, resulting in strong evolutionary constraints.
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KSG wrote Perl scripts, contributed to analyses involving BLAST and retrotransposon sequences and contributed to manuscript preparation.
bp, base pair nt, nucleotide Mb, megabase MP created the pipeline for identification and automatic annotation of SLSs within bacterial sequences and contributed to sequence and statistical analysis.
DEG conceived the study, participated in its design, identified most of the gene sequences and contributed to the manuscript.
VK participated in conceiving the research, providing the 454 sequences, and contributed to writing of the manuscript.
CG contributed to data analysis, performed comparative mapping with zebrafish and tentative annotation of rainbow trout sequences and contributed to manuscript drafting.
RC and KH generated the COI sequences, and contributed the majority of the native-range and the Hawaiian samples for genetic analyses.
TC and TR generated the rRNA sequences and contributed the majority of the continental U.S. and museum samples for genetic analyses.
Our data will serve to establish the functional and evolutionary significance of these sequences and contribute to their future use as molecular markers.
Retrocopies provide the means for modifying splice patterns of genes [ 44], potentially adding entirely new protein coding sequences, and contributing non-protein coding RNA or regulatory sequences, thereby expanding the possibilities to shape gene evolution.
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