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b Gene structure and the sequence variance of GNS4 between WT and the gns4 mutant.
This is less than half as frequent as previous reports of sequence variance between M. musculus and M. spretus [ 5].
Intronic sequence variance would only impact transcript levels through alteration of miRNA sequences or by location in the promoter region.
ViVan is a complete pipeline facilitating the identification, characterization and comparison of sequence variance in deep sequenced virus populations.
The relative lack of amino acid sequence variance per nucleotide change may be associated with the role of the kinase domain in the signaling function.
Further extensive sequence variance analysis would be required before tools such as siRNA gene silencing could be applied to silence the expression of Glo-3 genes.
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Validation of cell lysate-based PMCA introduces a convenient model system that provides unlimited flexibility in functional analysis of PrP conversion associated with diverse PrP sequence variances.
These results suggest that the sequence variances located within the C-terminal region of the C. armatus LDH-b must contribute to catalysis, even if they are far removed from the active site.
The identification of the functional roles of sequence variances in human orthologs of Drosophila genes may provide critical insight in the prioritization of candidate genes in human, which may fail using conventional statistical techniques.
Third, we introduce a new method to identify mutation mediated pathway profiles, which can be used to prioritize driver mutations and epistasis, by integrating sequence variances, protein-protein interaction networks, and gene expression profiles.
This again indicates that sequence variances between Arabidopsis and potato PDX proteins are responsible for this difference in interaction behavior, since AtPDX1.2 and StPDX1.2 are also only 69% identical.
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