Tallimustine is not region specific, despite the very high sequence specificity.
In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specificity in vitro or in vivo.
Wu RA, Collins K. Sequence specificity of human telomerase.
A motif-independent metric for DNA sequence specificity.
Among them, SigB and SigH have a distinct promoter sequence specificity compared to the SigA31,44.
Weirauch, M. T. et al. Determination and inference of eukaryotic transcription factor sequence specificity.
However, current investigation is hampered by the lack of computational methods for systematic evaluating sequence specificity.
David Liu and colleagues developed a series of variant Cas9 proteins (xCas9) that have a broader sequence specificity.
The variation in recognition sequence specificity could be used to tune the number of genes targeted by MazF.
Gruenbaum, Y., Naveh-Many, T., Cedar, H. & Razin, A. Sequence specificity of methylation in higher plant DNA.
