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The mean CI for each sequence regimen is presented in Figures 5a and b, showing a sequence-dependent synergy, with better antileukemic activity when the cells were exposed to cytarabine or daunorubicin simultaneously or for 24 h before adding AKN-028, whereas antagonism was observed when cells were pre-treated with AKN-028.
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Sophisticated sequencing regimens designed to exploit different mechanisms of action have the potential to confer greater clinical benefit than the historical approach of selecting the agent with the next highest single-agent clinical activity upon disease progression.
In comparison, the ORR in sequenced-regimen group was only 20%.
However, the information obtained from these studies does provide further evidence with regard to establishing sequencing regimens.
We attempted to limit these confounding variables by randomizing the sequence of regimens.
In this subset of patients we observed no convincing efficacy of either of the common sequence therapy regimens.
While combinations of S-1 with DDP, CPT-11, and docetaxel will be confirmed by phase III studies, how to best sequence these regimens following late recurrences after S-1 adjuvant therapy remains unknown.
This allows me to see at a glance the sequence of regimens a patient has received, the virological response, when resistance testing was obtained, the current CD4, the CD4 nadir just about everything one needs to know to manage the increasingly complex chemotherapy of HIV.
Alternatively it should be useful to identify rapid succession regimens in which biologic drugs are taken according to an established sequence.
The primary end point is the distribution of patients receiving unique treatment regimens or a sequence of treatment regimens for HER2-positive MBC.
The same sequence of antibiotic regimen is then repeated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com