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They could reach prediction accuracies around 80%, which partially confirms people's speculation that there may exit sequence propensity for genomic DNA methylation.
We previously explored the sequence propensity to form amyloid using variants of a designed peptide with sequence KFFEAAAKKFFE.
Random positioning and the apparent lack of sequence propensity are suggestive of sequence-nonspecific DSB mechanisms such as oxidative free radicals, ionizing radiation, or less commonly, spontaneous DNA backbone hydrolysis.
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PPII do not display strong sequence propensities in contrast to the other extended conformations, such as β-strands [37].
Two example β-strand classes are shown which again differ in their sequence propensities.
Their study also highlighted position‐specific sequence propensities of amino‐acids and the occurrence of the GxxxG motif.
The careful annotation of well-described MoRFs in terms of their sequence propensities or interaction interfaces as well as their known binding partners, and integration of these annotations with MoRF predictions, would likely improve the use of these predictions for gaining insight into IDR functionality.
According to our data, in E. coli polypeptides, these effects are partially compensated by an overall decreased sequence aggregation propensity.
Their ubiquitous presence genomically, combined with their relatively conserved sequence and propensity of methyl-CpG targets, highlights their appeal as a representative measure of global methylation.
We propose that with extensive sequencing the propensity for false positive miRNA identification increases dramatically if low abundance siRNAs are considered.
This distinguishing behavior is reflected by differential, sequence-directed propensity for nucleosome occupancy between the two classes, which displays evolutionary conservation and may be important for governing differential expression noise between the two classes.
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