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Using iterated sequence profile searches, we obtained an extensive list of proteins carrying the PAM2 motif.
Zhou, H. & Zhou, Y. Single body knowledge based potentials based energy score combined with sequence profile and secondary structure information for fold recognition, Protein 55, 1005 1013 (2004).
It is not surprising, as most of the disorder predictors use sequence profiles to perform the predictions and point mutations do not impact the sequence profile significantly.
Using sequence profile analysis and sequence-based structure predictions, we define a previously unrecognized, widespread class of P-loop NTPases.
The profile is generated by combining the sequence profile generated by PSI-BLAST and a structural profile generated by shape string blocks.
The generalized sequence profile method and the pftools package [7] were used.
The sequence profile is then used to generate secondary structure and solvent accessibility predictions.
The members of the D. discoideum actinome were identified according to their 'actin sequence profile'.
Eight proteins with a characteristic actin sequence profile are homologues to known actin-related proteins (Arps, Fig. 1).
The edited sequence was compared to the UniRef100 database using PSI-BLAST[12] to construct a sequence profile.
A limitation of PSI-Blast as a search tool is that it employs a sequence profile, which contains less information than the original MSA used to create it.
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