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To decipher the mechanism of this effect, we studied in BxPC-3 human pancreatic cancer cells the sequence of signaling events leading from NO-ASA treatment to cell growth inhibition.
Within the intermediate mesoderm, specification of renal progenitor cells follows a precise temporal and spatial sequence of signaling events [6], [7].
Our assay will be useful to study the temporal sequence of signaling events the lead to the formation of cortical plaques during gonococcal infection and should be applicable to other pathogens that generate T4P including N. meningiditis, or Pseudomonas aeruginosa.
Nonetheless, selective early activation of the CREB pathway by M. vaccae was reflected in the transcriptional response, suggesting that the temporal relationship or sequence of signaling events is functionally important, and supported reports that transcriptional regulation by NFκB may compete and antagonize CREB-dependent regulation [53].
Apoptotic process is a complex sequence of signaling events and metabolic changes.
In other words, Figure 2a depicts a putative sequence of signaling events that could occur in a single hepatocyte after insulin stimulation.
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These appear to orchestrate a sequence of signalling events resulting in the progressive development of FD.
Further studies are needed to examine the complexity of the sequence of signalling events which interplay with biomechanical and matrix fragment signals for early OA therapeutic intervention.
Each step of leukocyte migration relies on a well-coordinated sequence of signalling events that exert a tight spatiotemporal regulation of cytoskeletal dynamics (Renkawitz and Sixt, 2010).
It results in damage to subcellular organelles and nucleic acids and causes protein aggregation as well as alternations to a sequence of signalling cascades that affect cell apoptosis, ageing and autophagy.
To me as a layman, it looks like a sequence of signals that were given out by the aircraft possibly indicating its flight path," he said.
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