To the best of our knowledge, in humans, because of the limitations of PCR-based genotyping, the relationship of sequence properties of human microsatellites and properties of microsatellite genetic diversity has yet to be explored in detail.
Our study provides the most comprehensive evaluation to date of the effect of sequence properties of microsatellites on microsatellite variability in human populations.
Page 11: Paragraph under the section "Analysis of sequence properties of proteins involved in host-pathogen PPIs".
D-Tailor provides an integrated Python-scripting framework for multidimensional analysis of sequence properties and for the design of artificial sequences constrained by multiple sequence properties of interest.
To improve our understanding of the sequence properties of the unique FRT-like sequences and to help identify the ones with similar sequence patterns, we grouped both the duplicated and unique FRT-like sites into classes based on the number of matches (8, 7, 6, or 5) to the corresponding positions of FRT in the proximal-8 region (Figure 1A).
In all, a total of 110 KNL1 orthologs, displaying a great variety of sequence properties, were used in this study (supplementary sequence file, Supplementary Material online).
The relatively large number of microsatellites examined here has enabled us to consider the relationships with microsatellite heterozygosity of a wide variety of sequence properties.
The analysis of the sequence properties of proteins involved in host-pathogen PPI network reveals many interesting properties that have not been reported before.
First, it allows the definition of multiple design targets as combinations of sequence properties that embody particular DoE.
The DoE enumerates combinations of sequence properties that need to be generated, each of which constitutes a design target.
