Sentence examples for sequence of mutations from inspiring English sources

Using network deconvolution, they then generate a tumor evolutionary directed graph that provides a general model for the sequence of mutations.

Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

It is preferable for the fitness of solutions to change smoothly as they evolve, with improvements in fitness tied directly to particular sections of the chromosome, rather than relying on a very specific sequence of mutations to occasionally create a large improvement in fitness.

In our study, three of the four samples with the 164L mutation also contained ≥ three mutations in other codons, indicating that the next step in the sequence of mutations has been reached.

Reversion to the HIV-1 subtype B consensus sequence of mutations in- and outside donor-HLA-restricted CTL epitopes, and new mutations away from the consensus B sequence mostly within recipient-HLA-restricted epitopes, contributed equally to the early sequence changes.

The genetic alterations and the possible sequence of mutations needed for the progression to melanoma are still to be defined.

The cluster algebra is generated by the variables obtained from all possible sequences of mutations.

The model is also capable of predicting changes in both tissue composition and in the progression of cells along their lineage at any given time and for various sequences of mutations.

Further, Sanger sequencing of mutations has a limited detection level, particularly for heterozygous mutations in impure, heterogeneous tumour samples.

It has been of major interest to reduce the amount of brute force screening by PCR genotyping and sequencing of mutations.

Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness and eventually metastasis.