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In that uncertainty, medical investigators could never quite discern the sequence of infection that began with Johanna Huden.
The sequence of infection is unknown and only a follow up study can determine which condition facilitates the other.
The first stage used Illumina sequence of infection phenotype pools as genotyping, in order to rapidly highlight candidate loci.
16 We did not have information on sequence of infection by different dengue serotypes and therefore we cannot compare with previous studies that have examined this.
In contrast, only ≈3% of CHIKV+ patients were also DENV-2+; however, the starting period of time of infection or the sequence of infection by the 2 viruses cannot be assessed.
Using the transparent Daphnia hosts and fluorescently-labelled spores of the bacterium P. ramosa, we identified a sequence of infection steps: encounter between parasite and host; activation of parasite dormant spores; attachment of spores to the host; and parasite proliferation inside the host.
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In other geographic areas, the sequence of infections is less clear.
For comparison purposes, we simulated the stochastic version of the model using a Markov Chain Monte Carlo method and observed sequences of infection waves for different sets of parameter values (see Appendix).
Future research in this direction should address some limitations of the present study, including a systematic exploration of parameter space to characterize which intervention parameter regimes are more likely to give rise to sequences of infection outbreaks, and to determine the sensitivity of model outputs (epidemic dynamics) on parameter changes.
These simulations indicate that variation in the transmissibility of the pathogen (determined by R0 ), as well as parameters that govern the effectiveness of control measures can significantly impact the epidemic profile, leading to sequences of infection waves with different magnitudes and time-courses.
We develop mean-field and stochastic epidemiological models for disease transmission, and perform simulations to show how control measures, such as drug treatment and isolation of ill individuals, can influence the epidemic profile and generate sequences of infection waves with different characteristics.
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