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Integration of such signals can result in alteration of the otherwise quiescent state of MSCs, eliciting a sequence of fate choices that may include proliferation, self-renewal, migration, differentiation and cell death.
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Such temporal competence factors are clearly seen in Drosophila CNS neuroblasts, where a sequence of fate-influencing TFs starting with Hunchback are expressed [ 35].
This balance could be regulated at the level of individual RGPs, which might undergo defined sequences of fate choices during progenitor amplification and neurogenesis.
The actual evolutionary process leading to this "strip-down" becomes easy to conjecture if one recalls the sequence of cell fate determination steps during normal ommatidial development (Fig. 8).
Thus, the sequence of cell fate allocation occurs normally at the rhombic lip despite a non-autonomous reduction in FGF signalling and accompanying cerebellar size reduction.
A recent publication showed that a stochastic version of the floral GRN model recovers a temporal sequence of cell-fate attainment that mimics that observed in most flowers: once sepal primordia are determined, then petal are differentiated next, and then stamen and carpel primordia are determined [10].
In a wry twist of fate, sequencing has become a key tool for defining structure.
This complex sequence of events determines the fate of young and genetically identical larvae to switch into either reproductive a queen or infertile worker honeybee castes.
Such a hierarchical sequence of mostly binary cell fate decisions appears to be a universal mechanism through which higher metazoan produce the diversity of cell types and has been well studied in hematopoiesis, neurogenesis and in early embryo development [14], [20], [21], [22], [23].
As the spectral absorption properties of a visual pigment are mainly determined by the amino acid sequence of its opsins, the fate of an opsin is related to both the function and the history of a photoreceptive structure.
"Out-of-fate Baileys?
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