Many genetic diseases are caused by mutations, or changes in the DNA sequence of a gene, that make it produce a dysfunctional protein product.
One relied on the DNA sequence of a gene called cytochrome oxidase.
Under her deal with Amgen, the company gets a look at the sequence of a gene before she publishes it, to see whether it is worth patenting, she said; so far, no genes have qualified.
In December , 1987 biologists at the Research Institute of Microbial Diseases, in Osaka, Japan, published the DNA sequence of a gene taken from the common intestinal bacterium E. coli.
The nucleotide sequence of a gene has been "edited" into its present form by natural selection because it "makes sense".
If the sequence of a gene is known, it can take only weeks to synthesize a corresponding messenger RNA.
By patenting the cDNA sequence of a gene and its variants, GMO companies can prevent others from introducing the gene to any other plants without having to obtain individual patents for each plant.
But after examining blood samples from five families in the United States, Britain, South Korea and Brazil, Dr. Kaplan and Eileen Shore, a colleague, found that the rampant bone growth begins with a tiny error in the nucleotide sequence of a gene that serves as a blueprint for a protein called ACVR1.
In the present study, we identified the cDNA sequence of a gene encoding phormicin in B. dorsalis.
During a medical fellowship at Duke in Robert Lefkowitz's lab in the mid-1980s, Kobilka played an instrumental role in determining the exact sequence of a gene for a particular GPCR called the beta-adrenaline receptor.
Based on their previous work, they suspected that if a specific seven nucleotide stretch of an miRNA matched the sequence of a gene, that miRNA regulated that gene.
