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This list of all acetylated peptides detected included the precursor m/z, charge state, retention time, search score, sequence, modification, and protein name for each acetylated peptide.
This sequence modification had no effect on the silencing efficiency of the siRNA.
In the current study, we attempted to optimize peptide bioactivity by sequence modification and assess the antimicrobial activities.
Here we report a novel system to select sgRNA with high efficacy for DNA sequence modification by a luciferase assay.
Nucleotide sequence modification through single base editing in animals is emerging as an important player in tumorigenesis.
Our data suggest that this sequence modification coupled with structural modification differentially recruits human TLR8 over TLR7, and could have potential application in antiviral therapies.
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Heritable changes in gene expression that do not involve coding sequence modifications are referred to as "epigenetic".
Sequence modifications to the protein and changes in fermentation conditions resulted in increased potency and greater consistency of the product.
Thus far, however, even in easy-to-manipulate yeast, genes had to be deleted one-gene at a time, often with additional undesired sequence modifications left behind in their genome.
Here we report bivalent/bispecific single-domain proteins based on the kringle domain (KD), which has a cystine knot structural motif and is highly tolerant of sequence modifications.
Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome.
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