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Metabolic reconstruction was introduced more than 10 years back as a method of genome sequence interpretation.
The final sequence interpretation scheme is obtained based on the correlation and the verification of the seismic profile with the sequence interpretation scheme on well logs after a depth-time conversion.
Sequence interpretation for individual peptides was performed using the PepSeq MASCOT tool of the MassLynx™ 4.0 software package (Waters).
PCR and sequence interpretation were performed blinded to the microscopy results.
By virtue of increased complexity, this paradigm shift in genetic testing has been accompanied by new challenges in sequence interpretation.
The base sequence interpretation of the chromatograms and SNP genotype recognition were implemented automatically by the software and checked manually.
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Although interpretation of mass spectra using de novo tools has made considerable progress, the approach remains challenged by the shear number of possible amino acid sequence interpretations for measured fragmentation mass spectrum [3], [4].
Subsequently, a separate group of judges, who can use video replay to scrutinise every step in depth, rates each element on a grade of execution (GOE) ranging from -3 to +3, as well as assigning points for skating skills, transitions, step sequences, interpretation and timing.
The modularity of VariantDB offers extensibility with field-specific (for example, COSMIC for cancer research) and future (for example, ENCODE for whole genome sequencing interpretation) annotations and annotation tools in local instances.
Open image in new window Fig. 2 Sequence stratigraphic interpretation on an EW regional seismic line.
The sequence stratigraphy interpretation of well logs permitted us to recognize thirteen depositional sequences and the stratigraphic signatures of the rift stages.
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