Sentence examples for sequence incompatibilities from inspiring English sources
If the mutations are mutually exclusive, sequence incompatibilities may arise rapidly.
Although both steps narrowed down the number of transcripts analyzed to select candidates for brain eQTL mapping, they permit selection of transcripts consistently measured across the samples despite possible sequence incompatibilities in cross species hybridizations.
Owing to sequence incompatibilities in cross-species hybridization, the lists of genes selected based on gene expression measures may be biased against rapidly evolving genes and therefore functional categories attributable to such genes may appear as underrepresented in our analysis.
We used intermediate size oligonucleotides expecting that these probes would sufficiently tolerate sequence incompatibilities between human probe sequence and vervet target transcripts and be more robust than shorter probes to possible allelo-specific differences in hybridization efficiency due to vervet-specific SNP variants occurring in probe-interaction sites (40).
However, the term "incompatibility" has been expanded to include the protein level by the community (e.g. "protein sequence incompatibility" (Wellner et al., 2013), "incompatible mutations" (Lunzer et al., 2010), "Dobzhansky-Mueller incompatibility" (Kondrashov, Sunyaev and Kondrashov, 2002)).
In other studies, we have found that the NS5A change was consistently selected for in all viruses rescued in vivo from the wild-type GBV-B molecular clone used here [3], [5], therefore we hypothesized that this mutation was not directly compensating for a sequence incompatibility within the chimeric genome.
Many amino acid exchanges between the new and original enzyme are not tolerated, implying sequence incompatibility.
Initial sequencing with the HLA-1 forward primer revealed a sequence incompatibility with most HLA-A alleles, leading to the generation of a short, chimeric DNA bead which interfered with genotyping Additional file 4: Figure S1.
To evaluate the impact of probe-target sequence incompatibility in our data set, we compared the number of probes widely detected in vervet brain tissues (at least 80% of tissues) and in 193 human cortical samples analyzed by Myers et al. (5), using 6791 probes that are in common between the two data sets.
Further, we find longer sequences develop incompatibilities more quickly at small population sizes, but more slowly at large population sizes.
Moreover, the process responsible for the percept sequence accelerates with increased incompatibility between two monocular stimuli, and may involve the comparison of two monocular stimuli to establish the degree of binocular correspondence.
