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Bi-directional sequence exchange between the recombined genes occurs with crossover, while uni-directional sequence exchange occurs in absence of crossover.
This lack of bi-directional sequence exchange supports the notion that the HBB gene was repaired primarily through non-crossover HDR (San Filippo et al., 2008).
Sequence comparisons suggested that paralogs of this resistance locus evolved through recent gene duplication, and were subjected to frequent sequence exchange.
Thus, plant immune systems and pathogen effector systems mirror each other in an additional way, by relying on gene clusters and associated sequence exchange mechanisms to provide rapid and novel changes to genes that control immunity and virulence.
These RFLPs belong to 2 3 independent linkage groups, which are distributed on several chromosomes and stable among mouse strains (i.e., inter-group sequence exchange is rare) [8], [16], [17].
This organization can promote unequal recombination, which results in sequence exchange between paralogs and generation of recombinant genes with new resistance gene specificities, as well as expansion/contraction of gene copy number [26].
Similar(12)
Taken together, these results indicate that non-homologous sequence exchanges (homogenization) among different mouse v-rDNAs are rare [17].
Gain of virulence was acquired through mutation and subsequent sequence exchanges between the two copies of Avr3c.
Rather, these changes must have occurred in one copy and then spread to the second copy by sequence exchanges.
The arrangement of Avr genes in clusters offers opportunities for variation generated by sequence exchanges via unequal crossing over, homologous recombination, or gene conversion.
The finding that Avr3c is a multi-copy RXLR effector that acquired gain of virulence mutations that spread through sequence exchanges provides a new example of the plasticity of the RXLR effector family.
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