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This possibility had been predicted by Hendrich and Tweedie based upon sequence examination [15].
Sequence examination suggests the mechanism illustrated in Fig. 3D: recombination between the right x sequence of the upper allele and the left x sequence of the lower allele.
These features were only noticed after careful sequence examination and cannot be revealed with standard sequence comparison tools.
Detailed sequence examination indicated that some of these gaps and/or inversions were associated with integrative elements.
Detailed sequence examination revealed that some of these gaps and/or inversions were associated with integrative and conjugative elements.
In conclusion, we used a functional comparative genomics approach that combines bioinformatics sequence examination tools to mapping and phenotypical analysis of human mutations, to provide novel information on the organization in repeated domains of sacsin.
Similar(49)
Various sequence analyses and manipulations involving sequence alignments, conceptual translation, protein sequence examinations and calculations (e.g. molecular weight, isoelectric point) were carried out with Geneious v5.6 and v6.
On the other hand, the lack of group differences in brain activation patterns may also reflect an inadequate behavioral paradigm for movement sequencing examination.
Thus both the orphan reads from OEA and/or full orphan reads could be used to identify novel insertions where techniques such as mapping to primate sequences, examination of individual genomes, comparison to RNA-seq data, or PCR and sequencing are used to validate predicted novel insertions.
The sequence of examination continues to involve the three standard phases of clinical development, Phases I, II, and III, that evaluate safety, efficacy, and a specific endpoint, respectively.
Using a different filtering method at each stage we are able to exploit different compositional features of the sequence under examination.
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