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For instance, sequence discontinuity in the green palm domain was caused by insertion of the yellow fingers domain.
In contrast to both manual and automated domain definitions, SCOP rarely introduced sequence discontinuity in its classification of the first four structure classes (fig 2b SCOP).
Such an assignment resulted in a "composite" domain that could only be explained by multiple insertion events and resulted in sequence discontinuity (fig 1d red insertion into teal domain completes red composite domain).
Due to the fact that some cDNAs may contain more than one EcoRI sites and that EcoRI fragments were used to construct the normalized cDNA library, the final number of unique clusters could be overestimated when fragments generated from the same cDNA failed to form one cluster due to sequence discontinuity.
Alternatively, the extensions could result from a domain insertion event near the termini of an ancestral domain (fig 1b blue inserted domain splits pink ancestral domain), producing a sequence discontinuity in the ancestral domain (fig 1b blue segment splits pink segment).
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Most of these, however, display one or more sequence discontinuities known as stutters or stammers.
The genome substitution in Brujita can therefore be accounted for by two separate recombination events, one at each of the sequence discontinuities.
Any nucleosomal or sequence-composition discontinuity may feedback (in evolutionary time) toward favoring biased mutagenic "drift" in each domain that could retain the overall sequence organization.
This suggests that sequence coverage discontinuities may be useable as predictors of genomic termini in phage genomes.
However, for some input sequences motion discontinuities have the problem that they tend to oversegment the image, i.e. objects that do not exist are erroneously indicated.
This alternative led to a definition where the domains appeared terminally fused by sequence, with no discontinuity in either.
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