Unfortunately for the gene modeling programs which generated these sequences there are two gaps within the gene locus, and 118 bp of the EST contig sequence disappear into one or both of the gaps.
However, here it would be necessary to posit that prion gene sequences disappeared independently in most kingdoms of life except in chordates.
It is possible that some γ-gliadin sequences disappeared from the genome.
Seven sequences from the third round of SELEX contained only one motif or no recognizable motifs (each had a single occurrence); these sequences disappeared in later rounds of selection.
This sequence was then aligned with the genome contigs and scaffolds to identify the exact point where sequence identity disappeared.
However such sequences have disappeared long ago and can only be statistically estimated.
However, with only a small number of examples, it is difficult to know whether these observations are particular to certain types of genes and the average time period over which sequence similarity disappears.
We postulated that, if dsDNA gains access to these endosomes by BCR-mediated entry, the difference in potencies between double-stranded and single-stranded versions of the same inhibitory sequence would disappear.
This suggests that multiple recombination events at the same recognition site may have caused the repeat sequences to disappear.
In a very old cluster such as M67, which is 4.5 billion years old, all of the bright main-sequence stars have disappeared.
