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In any event, it is clear that the coding sequence density is, on average, very low in the hotspots.
This method allows for determining regions in sequence space in which the sequence density is significantly higher than average.
It is of note that these scenarios are not mutually exclusive, in that there may exist situations of stress where a chromatin domain may (or must) undergo deletion; it would be to the organism's advantage if the deletion occurred in a DNA domain of low coding sequence density.
In conclusion, deaminases preferentially target narrow focussed regions throughout the genome independent of the sequence density of deaminase targets.
The capture sequence density has been shown both experimentally and through modeling considerations to be a crucial parameter for achieving an optimal signal from hybridization [ 23, 24].
Human ENCODE Data: We used F-Seq [ 31] to generate continuous tag sequence density estimation in 1-bp resolution for all 30 data tracks.
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The four strains have similar coding sequence densities (from 80% to 86%).
In the case of detecting nucleic acid hybridization with polymerization-based amplification, an alternative and perhaps more feasible approach involves varying capture sequence densities.
This was in pair due to suboptimal sequence densities resulting in suboptimal clustering on the tiles of the Illumina Genome Analyzer (see methods section), resulting in poor sequence quality and low sequence output.
Although the genome maintenance genes in category L+ do have uptake sequence densities higher than average, they are not the highest ranked COG category in any species other than N. meningitidis.
The goal of this paper is to provide large deviations limit theorems for statistics, based on the delta-sequence density estimation and designed to symmetry testing of distribution.
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