De novo events including sequence alteration or copy number changes can impact gene function or alter dosage and contribute to mutational load.
Targeted sequence alteration would be an attractive method in gene therapy and biotechnology.
Rule 2 The sequence alteration is performed for each block of "NLV" vehicles.
The anticipated T → G sequence alteration was induced in the transgene in the liver with an efficiency of ∼0.1%.
Engineering can entail alteration of amino acid sequence, alteration of the glycocomponent of a glycosylated protein, or the covalent attachment of chemical moieties such as polyethylene glycol.
These observations support the hypothesis that genomic diversity driven by mutation or DNA sequence alteration and environmental adaptation may impact S. cerevisiae strain diversity more than geographical origin.
The model considers unintentional sequence alteration due to paint defects and the need of instant decision-making of the assembly line.
Intentional sequence alteration is needed to minimize costs related with downstream departments (Ding and Sun 2004; Sun et al. 2015; Lahmar et al. 2003; Boysen et al. 2012).
Unintentional sequence alteration occurs due to unpredictable sequence disturbances such as defective vehicles, material shortages, machine breakdowns and need instant solutions (Boysen and Zenker 2013; Inman 2003; Meissner 2010).
Furthermore, the newly identified sequence alteration p.F296L was only present in the control group with a frequency of 1.4%.
The structure changes required for AltS cases are much larger than those for other TSV cases, and these changes are mostly caused by significant precursor sequence alteration.
