The PTE column could provide significant advantages for difficult separation processes such as: separations that require a large number of theoretical stages, separations of large molecules that can be damaged by high shear stresses and separations of easily emulsifiable systems.
This has significant impact for samples from individuals with congenital DM1, for example, in which the repeat tract can be beyond 4 kb in size, but the viscoelastic matrix can be optimized to allow the separation of larger DNA fragments by, for example, reducing the PVP viscosity 15-fold (not shown).
This report describes the effects of fused-core particle size, pore size, shell thickness and ligand type for the rapid, efficient separation of larger molecules such as intact proteins and other biomacromolecules up to at least 400 kDa.
This suggests that the separation of larger particles (such as white blood cells) from a dense RBC background is simpler than separating smaller particles (such as platelets) from the same background.
This allows the separation of larger ribosome-associated mRNAs from translationally inactive sub-polysomal mRNAs.
The adapter has a pre-separator, for separation of large particles (i.e. carrier crystals) from the aerosol cloud before it is exposed to the laser beam.
It is commonly applied to the separation of large hydrocarbon molecules not volatile enough to be separated by gas chromatography, making RPLC especially relevant to oil analysis.
Separation of large DNA molecules by contour-clamped homogeneous electric fields.
This work provides an effective way to modify graphdiyne for the separation of large molecular gases, which is quite crucial in the gas separation industry.
However, for the separation of large biomolecules such as proteins, particles with large pore size (e.g. ≥ 300 Å) are needed to allow unrestricted diffusion inside the pores.
