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Chromatographic action causes spatial separation of product streams emerging from the annular exit.
The recirculation of impure fractions reduces the product losses and ensures separation of product to a high degree of purity.
Finally, this work has important implications for the separation of product related variants as well as the design of complex therapeutics for biomanufacturability.
The results are promising indications that multimodal chromatography using the appropriate multimodal ligands can be employed in downstream bioprocessing for challenging selective separation of product related variants.
Plant cell immobilization has a number of other processing advantages, such as re-use of cells (Brodelius et al. 1979), cultivation at higher cell densities, and separation of product and cells (Rosevear and Lambe 1983).
The hybrid reactor has potential applications to equilibrium limited reactions, in which selective adsorption of reaction species can lead to enhancement in conversion and bulk separation of product species.
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Immobilization not only enhanced enzyme properties but also facilitated the separation of products.
Separation of products and catalyst was realised using thermomorphic solvent systems (TMS).
However, separation of products and recycling of reactants in direct coupling reaction may require additional unit operations.
Currently, there is considerable industrial interest in multifunctional reactors involving in-situ separation of products from the reactants.
Rapid separation of products from reactants allows high conversions in both equilibrium limited and low per pass conversion reactions.
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