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Our results demonstrate the successful separation of pathways providing efficacy from side effects in muscular dystrophy.
Importantly, efficacy is maintained in the absence of immunosuppression and overt hormonal effects to growth and development, providing insight into mechanisms of glucocorticoids in muscular dystrophy and demonstrating a successful separation of pathways into dystrophy efficacy and side effects.
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The distinction that is made between genotype and phenotype is made necessary by the separation of causal pathways that lead on the one hand to the passage of information about organisms between successive generations, and, on the other, to the growth and development of an organism within a generation from conception to death.
Alternatively, the separation of the pathways may be dependent upon sorting of siRNAs following processing by the DCR-1/RDE-4 complex.
In species with multiple Che homologues, grouping of che genes into operons and localization of Che proteins into clusters in the cell are likely to be the major factors determining separation of chemotaxis pathways.
This provides a unique picture of the separation of metabolic pathways (synthesis, degradation and amino acid metabolism), but also the interaction between different lipid classes dependent on a single intracellular fatty acid pool.
Through the separation of different pathways in the graphical structure, it is possible to simulate an experiment (even in the absence of randomization) and, thus, separate causality from confounding.
Because of this separation of the two pathways used for processing touch, is that in some people with certain brain disorders, the physical sensation of pain can be separated from its emotional impact.
Spatial separation of CDK activation pathways is another possibility.
Morphological and molecular data speak in favour of a separation of the maturation pathways of SN and NSN oocytes and possibly a distinct fate within the ovary.
We propose that grouping of che genes into operons and localization of proteins into clusters in the cell are likely to be the major factors determining the separation of multiple chemotaxis pathways within a species.
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