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In that study, separation of genes by the rate of sequence evolution and by gene families has demonstrated that rodent-specific exons are more frequent in rapidly evolving genes and in rodent-specific paralogs [29].
This allows the separation of genes while avoiding the stochastic nature of k-means clustering.
The main effect observed on PC2 was showing the separation of genes by tissue as discussed above.
Firstly, the accuracy of gene expression models is substantially improved by unsupervised separation of genes into latent regulatory classes.
This separation of genes based on TFBS similarity indicates the presence of common cis-elements in the SST-regulated gene expression.
Thus, we focused on the gene module itself and examined the orientation and separation of genes in modules residing outside the cluster (Table 1).
Similar(46)
This property is clearly related to modularity as described here, a separation of gene effects on different unrelated traits.
Since the introduction of the dimerisation-deficient GR mutant, GRdim, was apparently unable to activate gene transcription, yet still able to repress pro-inflammatory gene transcription, the search for novel GR modulators has centred on the separation of gene activation from repression by prevention of GR dimerisation.
Analysis by gene expression microarray revealed a clear separation of gene signatures, with downstream activation of angiogenesis and down-regulation of genes involved in cell cycle regulation in SmoA1+/−; Pten +/− medulloblastomas.
Analysis revealed a clear separation of gene signatures, with up-regulation of genes in the PI-3 kinase signaling pathway, including downstream activation of angiogenesis in SmoA1+/−; Pten +/− medulloblastomas.
Nonetheless, the separation of gene sets is far from absolute.
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