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For each group separately, trials with outlier response times were removed from further analyses.
It was confirmed that presence of concurrent topical glaucoma agents did not alter the study findings by analyzing separately trials in which the patients were treated and untreated at baseline.
To improve the internal validity of this meta-analysis, we decided to consider separately trials of NPPV and CPAP, because these two methods have different technical, physiological and clinical characteristics.
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17 Within each meta-analysis we used random effects meta-analysis to estimate effect sizes separately for trials with and trials without exclusions of patients from the analysis.
21 We therefore considered patients with abdominal pain and patients with pain from musculoskeletal trauma as two separate populations and conceived two separately powered trials.
Trials recruiting over 60% children were analysed separately from trials on adults.
Models were run in the whole trial cohort and separately by trial group.
Models were also run separately by trial arm.
Models were also run separately by trial arm and by sex.
This was done separately for trials with different length of the delay and separately for the 2 conditions of interest, "Instructed" and "Self generated" trials.
RTs are plotted separately for trials where the target was specific and those where it was categorical.
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