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The overall frequency of adverse events was computed separately for each month and a Chi-square test for trend was used to test for a time trend in the prevalence of adverse events.
We fit one trajectory from presumed emergence through July using the electrofishing data, estimating κ separately for each month.
We fit city specific Poisson regressions to examine the effect of temperature on mortality separately for each month of the year, using penalized splines.
When comparing mortality rates with weather conditions in April and May, only lambs born in April and May were included and mortality records were examined separately for each month.
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The probability of dying was calculated directly from primary data and specified separately for each three-month cycle over the first 6 months on treatment, per 6-month period for months 6-12 and per annual period in months 12-24, 24-36 and 36-48 (no patients failed first-line in the first six months).
Confidence intervals for all proportions (using the binomial distribution) and a p-value for the comparison of estimated proportions between study groups (using the chi-squared test) separately for the 12 month and 6 month periods were calculated, adjusted for clustering by GP.
Regression models were estimated for each month separately and annually by curve estimation techniques with MINITAB statistical program.
Adherence was evaluated over the 3-month survey period as a whole and for each month separately to explore short-term changes in adherence.
For the Telephone Survey, annualised rates of IID in the community, presenting to general practice and contacting NHS Direct/NHS 24 will be estimated separately for one month and one week recall periods, after adjustment for seasonality, separately for each of the four countries, and for the UK overall.
The quantity of alcohol consumption was investigated by asking the respondents to report their average weekly consumption during the past month, separately for each type of alcoholic beverage.
Test persons reported illness (ill but not absent) and absenteeism (absent from work due to illness) days per month separately for each symptom.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com