We then performed stepwise conditional GWASs to prioritize separately associated SNPs owing to the potentially strong linkage disequilibrium (LD) between neighboring variants.
Pathway analysis of the differentially regulated genes and glycoproteins separately revealed pathways associated to metastasis including cell cycle regulation, immune response, and epithelial-to-mesenchymal-transition.
Moreover, this association clearly persists when we analyze pericentromeric, interstitial and subtelomeric regions separately (regions differentially associated to structural variations (Mefford and Trask, 2002; Bailey and Eichler, 2006)).
To assess the extent to which components of the metabolic syndrome drive the association with depressive symptoms, we calculated the percent attenuation in the metabolic syndrome depressive symptoms association after the components separately associated with depressive symptoms were added to the model.
To detect the independent acting locus in this region, we then carried out stepwise conditional GWA analysis to prioritize separately associated SNPs.
When gains and losses were separately considered, 7 regions remained significantly associated to prognosis in univariate analysis.
Multivariate analyses were conducted to identify patterns of behavior which were separately associated with engaging in UAIC and PAIC, using principal components analysis (PCA) and a hierarchical cluster analysis (HCA).
Long sleep duration (2.37 [1.16-4.89]), high risk of OSA (2.24 [1.09-4.75]), and excessive daytime sleepiness (3.27 [1.02-10.30]) were separately associated with VTDR.Sleep duration had a U-shaped association with moderate DR; long sleep duration, excessive daytime sleepiness and high risk of OSA were positively associated with VTDR.
caseload midwifery and CenteringPregnancy™ (a form of group antenatal care) are two models of maternity care that are separately associated with better clinical outcomes, maternal satisfaction scores and positive experiences compared to standard care.
In the time-to-event analysis (Table 3), poor self-rated health was separately associated with cardiac readmissions, cardiac events (with and without all-cause mortality), and all-cause mortality.
