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Moreover, as was recognized by Arvestad et al. [ 19, 20], explicit time modeling facilitates integration of separate time dependent evolutionary models into a unified framework.
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These observations are in accordance with the PCA that reveals two separate time-dependent influences on body weight variance among strains.
We further modified the Cox model to estimate the effects of smoking before and after stove improvement, with two separate time-dependent variables of smoking replacing the variable for overall effect of smoking.
Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.
Kcnn4 expression peaked during macrophage multinucleation and a separate time-dependent microarray analysis of fusing rat alveolar macrophages and human monocytes revealed Kcnn4 as a differentially expressed gene, which is strongly induced at the onset of fusion.
Cervical HPV status was controlled by constructing three separate time-dependent binary variables which measured whether a woman had ever been exposed to HPV16, HPV18 or other HPV types; HPV16 and HPV18, the two most common high-risk types, were detected in sufficient numbers to make this analysis feasible.
This method separates a time dependent signal into an infinite number of sine and cosine waves whose frequencies and amplitudes are displayed as a frequency spectrum.
This is due mainly to the rather misleading intuition that only harmonic vibrations can be described by solutions with separate time- and space-dependent factors.
For greater accuracy, load effects showing variance in time have been modeled by separating them into two random variables; time dependent r.v.
Separate experiments (results not shown) suggest that apart from the elevation of growth, there were no significant time dependent interactions with the filtering effect on the studied species.
A separate issue when working with a Cox PH model is possible PH assumption failure as when prognostic factors are time dependent; in other words, their hazards vary over time.
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