PDE subfamilies PDE1, PDE3, PDE4, PDE6, PDE7, PDE8, PDE9, PDE10 form separate specificity groups (that may include some unannotated sequences thus providing potential annotation for them), and subfamilies PDE2, PDE5, PDE11 form two specificity groups each.
In these latter cases, DPPIV activity may represent association with minimal amounts of CD26, which results in enhanced substrate hydrolysis, or may represent a separate enzyme specificity that can also accept DPPIV substrates.
These antibodies are not constant from one RA patient to another, but contain separate or overlapping specificities within the same peptide sequence varying between individuals.
However, after stratification for anti-CCP2 antibodies the association of anti-CarP antibodies and disease development remained significant in anti-CCP2 negative individuals irrespective of adjustments for each separate ACPA fine specificities or analysed as one group.
One question that arises with this prediction is just how valid it is to separate PATs in specificity groups when at least some of them have overlapping specificities.
We also illustrate that sensitivity and specificity separate two dimensions of the haplotype reconstruction error, which completely describe the misclassification matrix and thus provide the prerequisite for methods accounting for misclassification.
To clarify the complicated mechanisms of the Antidepressant-like effects generated by EA, we hypothesized the action of EA involved two parts with separate mechanisms: acupoint specificity and electrical stimulus.
For the analysis of tissue specificity of expression, two separate measures of tissue specificity were used: percentage breadth of expression and PEMMAX.
Additionally, MetaCyc includes many alternate pathway variants that only differ by one or two reactions, and these minor variants should not be counted as completely separate pathways when pathway specificity of a reaction is calculated.
Although the 16S rDNA regions are identical, the gyrB and recA sequences reveal that the endophytes of each plant species form separate clades, indicating host specificity of the bacteria at population level.
