Sentence examples for separate mutations at from inspiring English sources

Taken together, these findings highlight the remarkable ability of RT to use separate mutations at a single position to acquire NRTI resistance through three different mechanisms.

In this study, three separate mutations (M298F, V290N and V290A) were introduced at or near the T1 copper site of the small laccase (SLAC) from Streptomyces coelicolor A3(2) and biochemical properties were assessed in comparison with the native enzyme.

Mutation R143L was found in only one clone, while each of the three separate mutations in codon 572 were all found in at least two clones.

multiple, separate mutations responsible for the HD cases spread throughout Europe.

Recent studies suggest that multiple, separate mutations are more likely to explain Europe's uniform HD prevalence rates.

scientists were "not sure" of the level of threat posed by a separate mutation that helps the virus reach the lungs.

Alternatively, some mutations at separate genes open up a new biochemical pathway that circumvents the block of function caused by the original mutation.

In general, the interplay of multiple mutations cannot be ruled out as nonadditive energetic effects have been observed for mutations at positions separated by more than 9 Å [ 44].

The mutations at different positions, even distantly separated, are mutually coupled and form an evolutionary network.

Furthermore, these distinct activities can be separated by complementation of catalytically inactive IRE1 RNase and mutations at oligomerization interfaces.

The specificity and sensitivity attained by the transFIC of the three tools at separating highly recurrent from non-recurrent COSMIC mutations and recurrent from non-recurrent COSMIC mutations at each of these cutoffs are presented in Additional file 9.