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This model calls upon the existence of two completely separated groups (allopatry), where two separate mutations take place that would each have no effect on the reproductive fitness in the group in which they arise, but that would result in incompatibility between the groups if and when those two groups are brought back in contact with one another.
multiple, separate mutations responsible for the HD cases spread throughout Europe.
Recent studies suggest that multiple, separate mutations are more likely to explain Europe's uniform HD prevalence rates.
This tradeoff could be overcome by simultaneous introduction of separate mutations that improved mating efficiency alongside those that improved discrimination.
Recent studies suggest that multiple, separate mutations in Europe are the most probable explanation for its even geographic distribution of HD.
Last year, Sarah Tishkoff of the University of Maryland and colleagues tested 43 ethnic groups in East Africa and found three separate mutations, all different from the European one, that keep the lactase gene switched on in adulthood.
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scientists were "not sure" of the level of threat posed by a separate mutation that helps the virus reach the lungs.
In addition, separate mutation of three conserved residues Pro49, Pro52 and Lys54 – they are required for peptide recognition by SH3 domain –– in a designed peptide to Ala would completely abolish the capability of this peptide activating TIM.
Further, the ability to target separate mutation profiles to any number of regions along the gene allows emulation of complex mutation phenomena like hotspots.
When we obtained this strain, we immediately backcrossed it and found that the Mec phenotype is due to a separate mutation that is closely linked to glr-1.
Because transitions occur more frequently than transversions, we assume separate mutation rates for transitions and transversions.
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