The basic approach of this study was to first derive separate gene expression signature patterns of hormone independence from breast and prostate cancers and then to determine whether the two signatures shared significant similarity with each other.
It is well known that EOC constitutes a diverse set of malignancies, each with a separate histology, gene expression pattern [ 29] and outcome tightly linked to the underlying biology [ 4].
Hierarchical clustering identified six time-related gene expression patterns, which separated into three groups: two with early/transient responses, two with continuous/late responses and two with variable response patterns.
As anticipated, when the group number was set as 2, the transcriptional landscapes of the PABs and SABs separated into independent clusters, indicating distinct gene expression patterns for the two cell types (Fig. 2b).
Using unsupervised methods, cancer patients were separated into distinct groups based on gene expression patterns in one of the following pathways: apoptosis, cell cycle, angiogenesis, metastasis, p53, DNA repair, and several receptor-mediated signaling pathways including chemokines, EGF, FGF, HIF, MAP kinase, JAK and NF-κB.
The first situation was described for liver cancer in which separate tumors from a single patient showed dramatic differences in gene expression patterns [37].
The gene expression patterns in thiram-fed chickens at day 2 formed a separate cluster with similar gene expression patterns.
Our results demonstrate that it possible to separate patients with pathologically confirmed PSP, AD and FTD/PiD from each other based on their gene expression patterns.
In this paper, gene expression quantification is performed on a wide range of gene expression patterns from this database and descriptions of observed expression domains are stored in a separate database for further analysis.
Unsupervised analysis revealed distinct global gene expression patterns of endometrioid, papillary serous, mixed mullerian tumors, and normal tissues as grossly separated clusters.
