These distinct mechanisms are used to separate anxiety from anhedonia in animal models of depression.
One could argue that there are no separate anxiety and depression factors in the present sample.
It should be noted that the 4DSQ anxiety score is not able to distinguish between the separate anxiety disorder types.
However, if the child lacks expressive language skills, even caregivers may struggle to separate anxiety and ASD symptomology [ 11].
According to existing literature and our factor analysis, it is not possible to separate anxiety from depression in SCL-5.
The presentation of anxiety in the paediatric ASD population is fundamentally different from the anxiety seen in typically developing children and there is a general lack of means to separate anxiety from core ASD symptomology [ 10].
In a similar manner, phenotypes reflecting locomotor activity or exploratory drive in the EPM and OF showed their highest loadings on two separate anxiety-independent PCs (PC5 and PC1, Table 2).
The independent variables were sex and baseline information on age, separate anxiety and depression measures from the Hospital Anxiety and Depression Scale (HADS), alcohol use, insomnia and body mass index (BMI).
The findings are in keeping with the notion that anxiety seems to be a prominent feature or correlate of SM, although they remain silent with regard to the debate whether SM should be regarded as a separate anxiety disorder or merely represents a prodromal or extreme version of social anxiety disorder [ 41].
A candidate screening tool that has been widely and increasingly used with CHD patients is the Hospital Anxiety and Depression Scale (HADS: [ 12]), an easily administered 14-item self-report measure comprising 7 anxiety items and 7 depression items from which separate anxiety and depression sub-scale scores are calculated [ 13].
Predictors of response (endogenous subtypes, age, previous episodes, duration and severity of present episode, comorbidity with separate anxiety, attention deficit, and conduct disorder) The number of patients who relapsed during the maintenance phase (referred to in the CSR and in this paper as "continuation phase").
