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The lateral hypothalamus is involved in mediating general arousal and sensory sensitization associated with motivational behavior (de Lecea et al. [2012]).
Interestingly, from our correlation analysis it emerges that the more pronounced the habituation, the more the CM number of headache days and sensory sensitization increase.
Moreover, from the analysis of high-frequency oscillations, it clearly emerges that this sensory sensitization may be explained by the fact that in both groups, the connections between the thalamus and cortex intensify compared to episodic migraine between attacks.
We further noted that the presence of such sensory sensitization depends on the class of drugs overused, since initial SSEP amplitudes were smaller in triptan overusers than in NSAIDs or combined overusers.
The HFO analysis suggests that this sensory sensitization may be explained by an increase in the strength of the connections between the thalamus and cortex compared to episodic migraine between attacks.
This would consist of a blend of sensory sensitization (deep mechanical hyperalgesia; [ 49]), de-sensitization (cutaneous hypoesthesia; [ 17]) and mental changes like strong anxiety and depression.
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In fact, both groups of patients were characterized by higher amplitudes after low numbers of median nerve electrical stimuli (block 1), reflecting sensory cortex sensitization, and by response habituation over sequential block averages.
In contrast, we found evidence that HDAC4 may be involved in sensory neuron sensitization.
For example, increased ERK activity can induce sensory neuron sensitization, mechanical hypersensitivity, and spontaneous pain.
One possible patho-physiological mechanism explaining differences in the location of the TrP referred pain can be related to a different clinical manifestation or degrees of trigeminal brain stem sensory nuclear complex sensitization relative to cervical/spinal sensitization.
Summarized below are the animal studies that evaluated MMA-induced nonspecific respiratory effects, sensory irritation, respiratory sensitization, and contact skin sensitization.
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