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While single knockdown of either c-Cbl or Cbl-b had some effect on sensitizing to death, double knockdown was consistently more effective, as shown in Fig 2C.
These observations point to the necessity to improve TRAIL-R1/R2-targeting therapies by combination with molecules sensitizing to cell death and at the same time inhibiting potentially harmful non-apoptotic signaling.
Current efforts in the design and exploitation of selective CA inhibitors deal with the structure-based rational search [ 11– 13] and with their potential as agents sensitizing to combined treatments in cancer [ 14].
To conclude, our data suggest that casp-mediated cleavage of Beclin-1 results in the localization of Beclin-1-C fragments at the mitochondria, sensitizing to apoptosis by enhancing the release of mitochondrial pro-death factors.
We show that p38α and p38β inhibition results in ROS upregulation and JNK activation, sensitizing to cisplatin-induced tumour cell death both in human cancer cells and in a mouse model of breast cancer.
Strikingly, mocetinostat had no further drug-sensitizing effect in hPaca2 with already high endogenous miR-203 and miR-200, and low ZEB1 (Fig 4C and Table 2), indicating that if ZEB1 is not expressed and both microRNAs are already present, mocetinostat is less effective in sensitizing to gemcitabine.
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On the flip side, I am particularly sensitive and sensitized to some of the ills of earthly existence.
Eugenol, a frequent sensitizer, does not sensitize CYP1A1 knockout mice, whereas the wild-type mice are sensitized to eugenol.
"Ultimately, players have to be sensitized to it.
(The diabolic Knock and Ellen are from the very beginning sensitized to the vampire's approach).
Once sensitized to peanut proteins, subsequent exposures can result in allergic reactions that become increasingly serious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com