Sentence examples for sensitizing the cell from inspiring English sources

Thus, the genotoxic activity of doxorubicin activates the internal apoptosis pathway, while simultaneously sensitizing the cell to external, receptor-mediated apoptosis by the TRAIL ligand.

CHOP has been suggested to induce cell death through various mechanisms that include depleting cellular glutathione and sensitizing the cell to oxidative stress, upregulation of proapoptotic genes and downregulation of the prosurvival molecule Bcl-2.

It also mediates the regulation of the TGF-β1 pseudoreceptor BAMBI (bone morphogenic protein and active membrane bound inhibitor) in HSCs by TLR4-MyD88 acthustion, thusensitizingng the cell to TGF-β1 signaling [ 20].

Myc has also been found to decrease the TRAIL-induced increases (47) in Mcl-1 and cIAP2 by inhibition of nuclear factor-κB thus sensitizing the cell to the intrinsic pathway.

This protein is known for sensitizing the cell towards the mitochondrial activated pathway for apoptosis and could help explain why the cMycCHO cell appeared to have a longer stationary phase culture (with viability above 90%).

This is accompanied by a drastic reduction in p2l and 14-3-3σ 14-3-3σ 14-3-3σ thereby significantly sensitizing the cells to aproteins.

Previous investigators also revealed that apoptosis could be generated through the generation of reactive oxygen species which sensitizing the cells into curcumin [46].

Avicin D-induced dephosphorylation of Stat3 and the subsequent inhibition of its transcriptional activity, contributes to sensitizing the cells to apoptosis.

MF significantly arrested cells in G2 and M phases, apparently sensitizing the cells to RT. Conclusions.

ETS1 suppresses BRCA1/2 expression and impairs HR, thereby sensitizing the cells to the PARP inhibitor.

Treating the cells with BMP4 abolished the MDR phenotype, sensitizing the cells again to TMZ and other treatments.