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Possible mediators include triglycerides (TGs), catecholamines, acetaldehyde, alterations in insulin binding, and hepatic insulin sensitizing substance (HISS).
If some of the sensitizing substance remains there, it can reactivate the T cells, inducing a recurrence of inflammation.
The label on the packaging of mixtures containing at least one sensitizing substance in a concentration equal or greater than 0.1% …shall bear the statement: EUH208 'Contains (name of sensitizing substance).
Normally, mixtures which are not classified as sensitizing but contain at least one sensitizing substance in a concentration equal or greater than 0.1% must bear the supplemental label EUH208 'Contains (name of sensitizing substance) … May produce an allergic reaction.' ([1] Annex II Part 2 2.8) Table 1(C).
(C) Annex II Part 2 "2.8: Mixtures not classified as sensitizing but containing at least one sensitizing substance must be labelled according to the special rules for supplemental label elements for mixtures….
Light therapy is a method that involves delivering intense pulses of light to the area with acne sometimes following the application of a sensitizing substance (such as aminolevulinic acid).
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Irritant exposures can act as adjuvants among individuals exposed to sensitizing substances, increasing the proportion who become sensitized.
Tissue ischemia and hypoxia in the contraction knot may induce the secretion of sensitizing substances that cause pain.
The resulting tissue suffering induces the release of sensitizing, substances that activate nociceptors cause pain and contribute to maintaining and further aggravating the dysfunction of the motor endplate [ 28].
Based on the above findings, Simons suggested an "integrated hypothesis for MTrP," that considers excessive ACh release, sarcomere shortening, and the release of sensitizing substances as the essential features of MTrPs [ 1, 35, 36].
Shultz et al. [ 17] explained their results and recommended the usefulness of TrPs skin resistance measurement basing on Shah's findings [ 14], which confirmed the existence of a localized hypoxic region in TrPs and a local increase in sensitizing substances in that area possibly inducing locally greater blood flow and secretion from sweat glands via stimulation of the autonomic nervous system.
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