Sentence examples for sensitizing strategy for from inspiring English sources

Therefore, the pharmacological and/or genetic inhibition of autophagy was recently shown to sensitize cancer cells to the lethal effect of various cancer therapies, suggesting that the suppression of the authophagic pathways may represent a valuable sensitizing strategy for cancer therapy.

These studies led to the hypothesis that suppression of the autophagic pathway can be used as a sensitizing strategy for anticancer therapeutics.

This will allow the development of sensitizing strategies to circumvent adipose tissue-mediated resistance to trastuzumab in breast cancer.

Which TRAIL-apoptosis sensitizing strategies should be considered for novel therapeutic combinations to overcome TRAIL resistance?

The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial seeks to determine whether primarily using an insulin-sensitizing strategy for treatment of type 2 diabetes is superior when compared with primarily using an insulin-providing strategy with regard to cardiovascular outcomes.

This suggests a new strategy for sensitizing human cancers to MDM2 inhibitors.

Therefore, targeting TAZ in TAZ-overexpressed, T790M-induced resistance might be a novel therapeutic strategy for sensitizing EGFR-TKI treatment.

Although efflux pump inhibitors have yet to be established as a clinical strategy for sensitizing tumors to chemotherapeutic substances, genetic variations should be considered in the design of new therapeutic strategies.

The strong association between ER, PR, Bcl-2 and Bag-1 in our study suggests that co-targeting these molecules in hormone receptor-positive breast cancer might provide greater benefit than chemotherapy, or might be a beneficial strategy for sensitizing these tumors to chemotherapy – including in the node-positive subset of patients.

Pharmacological manipulation of XIAP therefore is a promising strategy to sensitize cells for TRAIL and to overcome TRAIL-resistance in case of central defects in the intrinsic apoptosis-signaling pathway.

Introduction of the tricysteine motif, which does not exist in any wild-type PTP, serves to sensitize target PTPs to inhibition by a biarsenical compound, providing a generalizable strategy for the generation of allosterically sensitized (as) PTPs.