One of the major findings of this paper is the sensitizing role for exogenous IFN in the treatment of pulmonary anthrax in vivo.
The finding of a sensitizing role for exogenous IFN, while surprising, has been described in other infectious models.
The effects of these compounds were enhanced by COX-2 inhibition suggesting a sensitizing role for COX-2-derived metabolites at TRPs.
Moreover, because AIP is inversely correlated with insulin sensitivity [ 36], this data together suggests that the insulin-sensitizing role of Pio would provide an antiatherogenic effect by targeting atherogenic dyslipidemia.
Glucose in OGTT was substantially declined, suggesting the insulin-sensitizing role of AE.
To investigate the role of Ser phosphorylation in mediating the insulin-sensitizing role of APPL1, we overexpressed RNAi-resistant wild-type and phosphorylation mutants (S401A and S401D) of APPL1 in APPL1-suppressed C2C12 cells.
A sensitizing role is conceivable in the conceptual framework of sensitive periods of brain and neuroendocrine systems maturation, during which emotional and sexual traumata exert particularly harmful influences, thereby sensitizing for psychopathological development [ 20, 23].
To effectively play their sensitizing role, these entities should be located at less than about 1 nm of an optically active Er ion. Figure 2 shows that the agglomeration of Si is favored by increased T d and/or film thickness.
Interestingly, earlier articles reported about a sensitizing and potentiating role of LiCl for TNF-α-mediated cytotoxicity [ 46, 47].
The unadjusted data indicate the relevance of multiple allergies for the highly atopic child, whereas the adjusted data demonstrate the role of a single sensitizing allergen and its significance for the further sensitizing process during childhood.
To identify regulatory mechanisms involved in CCL18 expression, a putative role of TNF-α as a sensitizing agent was investigated in cultures of blood PMN from healthy donors.
